Thyroid Hormone Disruption in Pregnancy and Postpartum Complications: A cross-sectional study


Thyroid hormone disruption; Pregnancy and Postpartum Complications; Quality of life for maternal and fetus.


Background: Thyroid hormone disruption as betimes leads to various complications both during pregnancy and in the postpartum period. Concerning maternal health, fetal development, and pregnancy outcomes, thyroid dysfunction can be adverse both in hyperthyroidism or hypothyroidism cases.

Objective: This study aimed to determine the analysis of clinical findings of patients with thyroid hormone disruption during pregnancy and postpartum complications.

Patients and methods: We conducted a cross-sectional study of women with thyroid hormone disruption, which include 77 cases which the participant's data was collected from different hospitals in Iraq during a period ranged from 14 July 2022 to 26 October 2023, where these variables include each of maternal age, parity, gestational age at the time of pregnancy termination, weight of newborns and quality of life rating.

Results: The current findings found the most women with thyroid hormone disorder was in 40 - 45 years which, include 34 cases, BMI divided into ≤18.5 with 4 cases, 18.6-24.9 with 50 cases, 25-29.9 with 20 cases, and ≥30 with 3 cases, gestational age 38 - 41, weeks had 43 cases, the cesarean section included 25 cases and vaginal delivery included 52 cases, types of pregnancy included singleton which have 68 cases, and twin had 9 cases, TSH was 4.02 ± 0.13, mU/L, Triiodothyronine was 172.02 ± 24.67, ng/dL, Thyroxine was 10.86 ± 3.56, mcg/dL, Thyroid peroxidase was 9.2 ± 0.8 IU/mL, Thyroglobulin was 113.84 ± 6.92 IU/mL, abortion had 3 cases, neonatal deaths was 4 cases, PPH had 2 cases, LSCS had 10 cases, low birth weight had 34 cases.

Conclusions: Hormone production in the thyroid rises during pregnancy, which pregnancy is a time when many women suffer aberrant thyroid function, with a significant risk of hyperthyroidism or hypothyroidism, both of which might lead to poor pregnancy outcomes as well as postnatal complications.